Ontology highlight
ABSTRACT:
SUBMITTER: Kakarla S
PROVIDER: S-EPMC4050065 | biostudies-literature | 2014 Mar-Apr
REPOSITORIES: biostudies-literature
Kakarla Sunitha S Gottschalk Stephen S
Cancer journal (Sudbury, Mass.) 20140301 2
Chimeric antigen receptor (CAR) T cells face a unique set of challenges in the context of solid tumors. To induce a favorable clinical outcome, CAR T cells have to surmount a series of increasingly arduous tasks. First, they have to be made specific for an antigen whose expression clearly demarcates tumor from normal tissue. Then, they must be able to home and penetrate the desmoplastic stroma that surrounds the tumor. Once within the tumor, they must expand, persist, and mediate cytotoxicity in ...[more]