Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4050357 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Chen Lu L Coleman Ronald R Leang Ronika R Tran Ha H Kopf Alexandra A Walsh Craig M CM Sears-Kraxberger Ilse I Steward Oswald O Macklin Wendy B WB Loring Jeanne F JF Lane Thomas E TE
Stem cell reports 20140515 6
Using a viral model of the demyelinating disease multiple sclerosis (MS), we show that intraspinal transplantation of human embryonic stem cell-derived neural precursor cells (hNPCs) results in sustained clinical recovery, although hNPCs were not detectable beyond day 8 posttransplantation. Improved motor skills were associated with a reduction in neuroinflammation, decreased demyelination, and enhanced remyelination. Evidence indicates that the reduced neuroinflammation is correlated with an in ...[more]