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Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.

ABSTRACT: In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a "proof of concept" for retinal sheet transplantation therapy for advanced retinal degenerative diseases.

SUBMITTER: Assawachananont J 

PROVIDER: S-EPMC4050483 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.

Assawachananont Juthaporn J   Mandai Michiko M   Okamoto Satoshi S   Yamada Chikako C   Eiraku Mototsugu M   Yonemura Shigenobu S   Sasai Yoshiki Y   Takahashi Masayo M  

Stem cell reports 20140424 5

In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a "proof of concept" for retinal sheet transplantation therapy for advanced retinal degenerative diseases. ...[more]

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