Ontology highlight
ABSTRACT:
SUBMITTER: Ibrahim AG
PROVIDER: S-EPMC4050492 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Ibrahim Ahmed Gamal-Eldin AG Cheng Ke K Marbán Eduardo E
Stem cell reports 20140508 5
The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be possible to regenerate injured heart muscle previously thought to be permanently scarred. The mechanisms of benefit are known to be indirect, but the mediators have yet to be identified. Here we pinpoint exosomes secreted by human CDCs as critical agents of regeneration and cardioprotection. CDC exosomes inhibit apoptosis and promote proliferation of cardiomyocytes, while enhancing angiogenesis. Injection of exosome ...[more]