Chemoselective enrichment for natural products discovery.
Ontology highlight
ABSTRACT:
SUBMITTER: Odendaal AY
PROVIDER: S-EPMC4051302 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Chemoselective enrichment for natural products discovery.
Odendaal Antoinette Y AY Trader Darci J DJ Carlson Erin E EE
Chemical science 20110128 4
Natural products account for a significant proportion of modern day therapeutic agents. However, the discovery of novel compounds is hindered by the isolation process, which often relies upon extraction and chromatographic separation techniques. These methods, which are dependent upon the physicochemical properties of the compounds, have a limited ability to both purify and concentrate the minor components of a biological extract. We have devised an isolation strategy based upon an orthogonal ch ...[more]
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