Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.
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ABSTRACT:
SUBMITTER: West BR
PROVIDER: S-EPMC4051510 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.
West Brandyn R BR Hastie Kathryn M KM Saphire Erica Ollmann EO
Acta crystallographica. Section D, Biological crystallography 20140530 Pt 6
The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus. ...[more]
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