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Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins.

ABSTRACT: Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding.

SUBMITTER: Gabrielsen M

PROVIDER: S-EPMC4051521 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins.

Gabrielsen Mads M Abdul-Rahman Puteri Shafinaz PS Othman Shatrah S Hashim Onn H OH Cogdell Richard J RJ

Acta crystallographica. Section F, Structural biology communications 20140524 Pt 6

Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together wit ...[more]

PMID: 24915077

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