Ontology highlight
ABSTRACT:
SUBMITTER: Favila MA
PROVIDER: S-EPMC4052223 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Favila Michelle A MA Geraci Nicholas S NS Zeng Erliang E Harker Brent B Condon David D Cotton Rachel N RN Jayakumar Asha A Tripathi Vinita V McDowell Mary Ann MA
Journal of immunology (Baltimore, Md. : 1950) 20140507 12
Leishmania major-infected human dendritic cells (DCs) exhibit a marked induction of IL-12, ultimately promoting a robust Th1-mediated response associated with parasite killing and protective immunity. The host cell transcription machinery associated with the specific IL-12 induction observed during L. major infection remains to be thoroughly elucidated. In this study, we used Affymetrix GeneChip (Affymetrix) to globally assess the host cell genes and pathways associated with early L. major infec ...[more]