Probing the average local structure of biomolecules using small-angle scattering and scaling laws.
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ABSTRACT:
SUBMITTER: Watson MC
PROVIDER: S-EPMC4052260 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Probing the average local structure of biomolecules using small-angle scattering and scaling laws.
Watson Max C MC Curtis Joseph E JE
Biophysical journal 20140601 11
Small-angle neutron and x-ray scattering have become invaluable tools for probing the nanostructure of molecules in solution. It was recently shown that the definite integral of the scattering profile exhibits a scaling (power-law) behavior with respect to molecular mass. We derive the origin of this relationship, and discuss how the integrated scattering profile can be used to identify differing levels of disorder over local ≲30 Å length scales. We apply our analysis to globular and intrinsical ...[more]
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