Ontology highlight
ABSTRACT:
SUBMITTER: Wu ZQ
PROVIDER: S-EPMC4052376 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Nature communications 20140604
Notch1-Delta-like 4 (Dll4) signalling controls vascular development by regulating endothelial cell (EC) targets that modulate vessel wall remodelling and arterial-venous specification. The molecular effectors that modulate Notch signalling during vascular development remain largely undefined. Here we demonstrate that the transcriptional repressor, Snail1, acts as a VEGF-induced regulator of Notch1 signalling and Dll4 expression. EC-specific Snail1 loss-of-function conditional knockout mice die i ...[more]