Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone.
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ABSTRACT:
SUBMITTER: Ryan ZC
PROVIDER: S-EPMC4052706 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone.
Ryan Zachary C ZC Craig Theodore A TA Salisbury Jeffrey L JL Carpio Lomeli R LR McGee-Lawrence Meghan M Westendorf Jennifer J JJ Kumar Rajiv R
Biochemical and biophysical research communications 20140426 1
We show that prostacyclin production is increased in bone and osteocytes from sclerostin (Sost) knockout mice which have greatly increased bone mass. The addition of prostacyclin or a prostacyclin analog to bone forming osteoblasts enhances differentiation and matrix mineralization of osteoblasts. The increase in prostacyclin synthesis is linked to increases in β-catenin concentrations and activity as shown by enhanced binding of lymphoid enhancer factor, Lef1, to promoter elements within the pr ...[more]
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