SLAP deficiency decreases dsDNA autoantibody production.
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ABSTRACT:
SUBMITTER: Peterson LK
PROVIDER: S-EPMC4053206 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
SLAP deficiency decreases dsDNA autoantibody production.
Peterson Lisa K LK Pennington Luke F LF Shaw Laura A LA Brown Meredith M Treacy Eric C EC Friend Samantha F SF Hatlevik Øyvind Ø Rubtsova Kira K Rubtsov Anatoly V AV Dragone Leonard L LL
Clinical immunology (Orlando, Fla.) 20131231 2
Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels and signaling in developing B cells. Based on this function, we asked whether SLAP deficiency could decrease the threshold for tolerance and eliminate development of autoreactive B cells in two models of autoantibody production. First, we sensitized mice with a dsDNA mimetope that causes an anti-dsDNA response. Despite equivalent production of anti-pept ...[more]
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