Is cancer vaccination feasible at older age?
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ABSTRACT:
SUBMITTER: Gravekamp C
PROVIDER: S-EPMC4053252 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Is cancer vaccination feasible at older age?
Gravekamp Claudia C Jahangir Arthee A
Experimental gerontology 20140206
Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor microenvironment (TME). This raises the question whether cancer vaccination is feasible at older age. We compared various cancer vaccine studies at young and old age, thereby focusing on the importance of ...[more]
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