Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux.
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ABSTRACT:
SUBMITTER: Luthi AJ
PROVIDER: S-EPMC4053472 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
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Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux.
Luthi Andrea J AJ Zhang Heng H Kim Dongwoo D Giljohann David A DA Mirkin Chad A CA Thaxton C Shad CS
ACS nano 20111201 1
Gold nanoparticles (Au NPs) were employed as templates to synthesize spherical, high-density lipoprotein (HDL) biomimics (HDL Au NPs) of different sizes and surface chemistries. The effect of size and surface chemistry on the cholesterol binding properties and the ability of the HDL Au NPs to efflux cholesterol from macrophage cells were measured. Results demonstrate that Au NPs may be utilized as templates to generate nanostructures with different physical characteristics that mimic natural HDL ...[more]
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