Ontology highlight
ABSTRACT:
SUBMITTER: Paredez AR
PROVIDER: S-EPMC4054273 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Paredez Alexander R AR Nayeri Arash A Xu Jennifer W JW Krtková Jana J Cande W Zacheus WZ
Eukaryotic cell 20140411 6
Consistent with its proposed status as an early branching eukaryote, Giardia has the most divergent actin of any eukaryote and lacks core actin regulators. Although conserved actin-binding proteins are missing from Giardia, its actin is utilized similarly to that of other eukaryotes and functions in core cellular processes such as cellular organization, endocytosis, and cytokinesis. We set out to identify actin-binding proteins in Giardia using affinity purification coupled with mass spectroscop ...[more]