Dataset Information

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan.

ABSTRACT:

Objective

The onset of acute myocardial infarction (AMI) shows characteristic circadian variations involving a definite morning peak and a less-defined night-time peak. However, the factors influencing the circadian patterns of AMI onset and their influence on morning and night-time peaks have not been fully elucidated.

Design, setting and participants

An analysis of patients registered between 1998 and 2008 in the Osaka Acute Coronary Insufficiency Study, which is a prospective, multicentre observational study of patients with AMI in the Osaka region of Japan. The present study included 7755 consecutive patients with a known time of AMI onset.

Main outcomes and measures

A mixture of two von Mises distributions was used to examine whether a circadian pattern of AMI had uniform, unimodal or bimodal distribution, and the likelihood ratio test was then used to select the best circadian pattern among them. The hierarchical likelihood ratio test was used to identify factors affecting the circadian patterns of AMI onset. The Kaplan-Meier method was used to estimate survival curves of 1-year mortality according to AMI onset time.

Results

The overall population had a bimodal circadian pattern of AMI onset characterised by a high and sharp morning peak and a lower and less-defined night-time peak (bimodal p<0.001). Although several lifestyle-related factors had a statistically significant association with the circadian patterns of AMI onset, serum triglyceride levels had the most prominent association with the circadian patterns of AMI onset. Patients with triglyceride ?150?mg/dL on admission had only one morning peak in the circadian pattern of AMI onset during weekdays, with no peaks detected on weekends, whereas all other subgroups had two peaks throughout the week.

Conclusions

The circadian pattern of AMI onset was characterised by bimodality. Notably, several lifestyle-related factors, particularly serum triglyceride levels, had a strong relation with the circadian pattern of AMI onset.

Trial registration number

UMIN000004575.

SUBMITTER: Edahiro R

PROVIDER: S-EPMC4054644 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan.

Edahiro Ryuya R Sakata Yasuhiko Y Nakatani Daisaku D Suna Shinichiro S Usami Masaya M Matsumoto Sen S Hara Masahiko M Kitamura Tetsuhisa T Sato Hiroshi H Yamashita Shizuya S Nanto Shinsuke S Hikoso Shungo S Sakata Yasushi Y Hori Masatsugu M Hamasaki Toshimitsu T Komuro Issei I

BMJ open 20140606 6

<h4>Objective</h4>The onset of acute myocardial infarction (AMI) shows characteristic circadian variations involving a definite morning peak and a less-defined night-time peak. However, the factors influencing the circadian patterns of AMI onset and their influence on morning and night-time peaks have not been fully elucidated.<h4>Design, setting and participants</h4>An analysis of patients registered between 1998 and 2008 in the Osaka Acute Coronary Insufficiency Study, which is a prospective, ...[more]

PMID: 24907246

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Dataset Information

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan.

Objective

Design, setting and participants

Main outcomes and measures

Results

Conclusions

Trial registration number

Publications

Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan.

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