Ontology highlight
ABSTRACT:
SUBMITTER: Dixon SJ
PROVIDER: S-EPMC4054777 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Dixon Scott J SJ Patel Darpan N DN Welsch Matthew M Skouta Rachid R Lee Eric D ED Hayano Miki M Thomas Ajit G AG Gleason Caroline E CE Tatonetti Nicholas P NP Slusher Barbara S BS Stockwell Brent R BR
eLife 20140520
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc (-) is implicated in numerous pathologies. Pharmacological agents that inhibit system xc (-) activity with high potency have long been sought, but have remained elusive. In this study, we report that the small molecule erastin is a potent, selective inhibitor of system xc (-). RNA sequencing revealed that inhibition of cystine-glutamate exchange leads to activation of an ER stress response and upregulation ...[more]