Ontology highlight
ABSTRACT:
SUBMITTER: Murrell M
PROVIDER: S-EPMC4055264 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Murrell Michael M Gardel Margaret L ML
Molecular biology of the cell 20140423 12
Myosin II motors embedded within the actin cortex generate contractile forces to modulate cell shape in essential behaviors, including polarization, migration, and division. In sarcomeres, myosin II-mediated sliding of antiparallel F-actin is tightly coupled to myofibril contraction. By contrast, cortical F-actin is highly disordered in polarity, orientation, and length. How the disordered nature of the actin cortex affects actin and myosin movements and resultant contraction is unknown. Here we ...[more]