Dataset Information

Human aqueous humor levels of TGF- ?2: relationship with axial length.

ABSTRACT:

Purpose

To analyze the relationship between transforming growth factor-beta 2 (TGF- ? 2) levels in the anterior chamber aqueous humor and axial length of patients with myopia.

Methods

TGF- ? 2 was measured with the Luminex xMAP Technology by using commercially available Milliplex xMAP Kits. Sixty-five aqueous humor samples were collected during cataract or clear lens extraction surgery and TGF- ? 2 levels in these specimens were analyzed. According to the axial length, the samples were divided into three groups: A (AL ? 24 mm), B (24 ~ 29 mm), and C (AL ? 29 mm).

Results

Aqueous humor samples were analyzed from subjects with an average age of 67.0 ± 11.7 years. Mean TGF- ? 2 concentration of all aqueous samples was 422.2 ± 258.8 pg/mL. TGF- ? 2 concentration in group C (543 ± 317 pg/mL) was significantly greater than that in group A (390 ± 212 pg/mL) and group B (337 ± 217 pg/mL). The concentration of TGF- ? 2 was positively correlated with axial length (r = 0.308, P = 0.013).

Conclusions

TGF- ? 2 is likely to be acting as a critical factor in axial elongation and development of myopia.

SUBMITTER: Jia Y

PROVIDER: S-EPMC4055366 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Human aqueous humor levels of TGF- β2: relationship with axial length.

Jia Yan Y Hu Dan-Ning DN Zhou Jibo J

BioMed research international 20140520

<h4>Purpose</h4>To analyze the relationship between transforming growth factor-beta 2 (TGF- β 2) levels in the anterior chamber aqueous humor and axial length of patients with myopia.<h4>Methods</h4>TGF- β 2 was measured with the Luminex xMAP Technology by using commercially available Milliplex xMAP Kits. Sixty-five aqueous humor samples were collected during cataract or clear lens extraction surgery and TGF- β 2 levels in these specimens were analyzed. According to the axial length, the samples ...[more]

PMID: 24967344

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