Ontology highlight
ABSTRACT:
SUBMITTER: Watari K
PROVIDER: S-EPMC4055709 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Watari Kosuke K Shibata Tomohiro T Kawahara Akihiko A Sata Ken-ichi K Nabeshima Hiroshi H Shinoda Ai A Abe Hideyuki H Azuma Koichi K Murakami Yuichi Y Izumi Hiroto H Takahashi Takashi T Kage Masayoshi M Kuwano Michihiko M Ono Mayumi M
PloS one 20140612 6
Tumors formed by a highly metastatic human lung cancer cell line are characterized by activated signaling via vascular endothelial growth factor (VEGF)-C through its receptor (VEGFR-3) and aggressive lymph node metastasis. In this study, we examined how these highly metastatic cancers acquired aggressive lymph node metastasis. Compared with their lower metastatic counterparts, the highly metastatic tumors formed by this cell line expressed higher amounts of interleukin (IL)-1α, with similarly au ...[more]