A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury.

ABSTRACT:

Introduction

Research into therapeutic hypothermia following traumatic brain injury has been characterised by small trials of poor methodological quality, producing variable results. The Cochrane review, published in 2009, now requires updating. The aim of this systematic review is to assess the effectiveness of the application of therapeutic hypothermia to reduce death and disability when administered to adult patients who have been admitted to hospital following traumatic brain injury.

Methods

Two authors extracted data from each trial. Unless stated in the trial report, relative risks and 95% confidence intervals (CIs) were calculated for each trial. We considered P < 0 · 05 to be statistically significant. We combined data from all trials to estimate the pooled risk rati

SUBMITTER: Crossley S 

PROVIDER: S-EPMC4056614 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature