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Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory.

ABSTRACT: To develop new magnetization-prepared imaging schemes based on a three-dimensional (3D) concentric cylinders trajectory.The 3D concentric cylinders trajectory, which is robust to off-resonance effects and timing delays while requiring fewer excitations than a comparable 3D Cartesian (3DFT) sequence, is used as the readout for magnetization-prepared sequences exploiting its inherently centric-ordered structure. Two applications: (i) T1 -weighted brain imaging with an inversion-recovery-prepared radiofrequency-spoiled gradient-echo (IR-SPGR) sequence, (ii) non-contrast-enhanced (NCE) peripheral angiography with a magnetization-prepared balanced steady-state free precession (bSSFP) sequence are presented to demonstrate the effectiveness of the proposed method. For peripheral angiography, the scan efficiency is further improved by interleaving different preparations at different rates and by carefully designing the sampling geometry for an efficient parallel imaging method.In vivo brain scans with an IR-SPGR sequence and lower extremity scans with a magnetization-prepared bSSFP sequence for NCE peripheral angiography both demonstrate that the proposed sequences with concentric cylinders effectively capture the transient magnetization-prepared contrast with faster scan times than a corresponding 3DFT sequence. The application of peripheral angiography also shows the feasibility of the proposed interleaving schemes and parallel imaging method.The 3D concentric cylinders trajectory is a robust and efficient readout that is well-suited for magnetization-prepared imaging.

SUBMITTER: Kwon KT

PROVIDER: S-EPMC4056679 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory.

Kwon Kie Tae KT Wu Holden H HH Shin Taehoon T Cukur Tolga T Lustig Michael M Nishimura Dwight G DG

Magnetic resonance in medicine 20130701 5

<h4>Purpose</h4>To develop new magnetization-prepared imaging schemes based on a three-dimensional (3D) concentric cylinders trajectory.<h4>Methods</h4>The 3D concentric cylinders trajectory, which is robust to off-resonance effects and timing delays while requiring fewer excitations than a comparable 3D Cartesian (3DFT) sequence, is used as the readout for magnetization-prepared sequences exploiting its inherently centric-ordered structure. Two applications: (i) T1 -weighted brain imaging with ...[more]

PMID: 23818212

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Project description:Water-suppressed MRS acquisition techniques have been the standard MRS approach used in research and for clinical scanning to date. The acquisition of a non-water-suppressed MRS spectrum is used for artefact correction, reconstruction of phased-array coil data and metabolite quantification. Here, a two-scan metabolite-cycling magnetic resonance spectroscopic imaging (MRSI) scheme that does not use water suppression is demonstrated and evaluated. Specifically, the feasibility of acquiring and quantifying short-echo (TE = 14 ms), two-dimensional stimulated echo acquisition mode (STEAM) MRSI spectra in the motor cortex is demonstrated on a 3 T MRI system. The increase in measurement time from the metabolite-cycling is counterbalanced by a time-efficient concentric ring k-space trajectory. To validate the technique, water-suppressed MRSI acquisitions were also performed for comparison. The proposed non-water-suppressed metabolite-cycling MRSI technique was tested for detection and correction of resonance frequency drifts due to subject motion and/or hardware instability, and the feasibility of high-resolution metabolic mapping over a whole brain slice was assessed. Our results show that the metabolite spectra and estimated concentrations are in agreement between non-water-suppressed and water-suppressed techniques. The achieved spectral quality, signal-to-noise ratio (SNR) > 20 and linewidth <7 Hz allowed reliable metabolic mapping of five major brain metabolites in the motor cortex with an in-plane resolution of 10 × 10 mm2 in 8 min and with a Cramér-Rao lower bound of less than 20% using LCModel analysis. In addition, the high SNR of the water peak of the non-water-suppressed technique enabled voxel-wise single-scan frequency, phase and eddy current correction. These findings demonstrate that our non-water-suppressed metabolite-cycling MRSI technique can perform robustly on 3 T MRI systems and within a clinically feasible acquisition time.

Dataset Information

Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory.

Publications

Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory.

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