Ontology highlight
ABSTRACT:
SUBMITTER: Chien R
PROVIDER: S-EPMC4056987 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Chien Richard R Zeng Weihua W Ball Alexander R AR Yokomori Kyoko K
Biochemistry and cell biology = Biochimie et biologie cellulaire 20110818 5
Cohesins are evolutionarily conserved essential multi-protein complexes that are important for higher-order chromatin organization. They play pivotal roles in the maintenance of genome integrity through mitotic chromosome regulation, DNA repair and replication, as well as gene regulation critical for proper development and cellular differentiation. In this review, we will discuss the multifaceted functions of mammalian cohesins and their apparent functional hierarchy in the cell, with particular ...[more]