Ontology highlight
ABSTRACT:
SUBMITTER: Zhong B
PROVIDER: S-EPMC4057015 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20140413
Tubulin and heat shock protein 27 (Hsp27) are well-characterized molecular targets for anti-cancer drug development. We previously identified lead compounds that inhibited both Hsp27 and tubulin. These compounds exhibited extensive anti-cancer activities against the proliferation of various human cancer cell lines. In the current study, a systematic ligand based structural optimization led to new analogs that significantly inhibited the growth of a panel of breast cancer cell lines. Furthermore, ...[more]