Ontology highlight
ABSTRACT:
SUBMITTER: Fox D
PROVIDER: S-EPMC4057648 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Fox David D Burgin Alex B AB Gurney Mark E ME
Cellular signalling 20131219 3
Phosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor -Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial cells. As such, it is an important, although under-exploited molecular target for anti-inflammatory drugs. This is due in part to the difficulty of developing selective PDE4B inhibitors as the amino acid sequence of the PDE4 active site is identical in all PDE4 subtypes (PDE4A-D). We show that highly selective PDE4B inhibitors can be designed ...[more]