Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC4057760 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Liu Zhiqian Z Fu Jianjun J Shan Lei L Sun Qingyan Q Zhang Weidong W
International journal of molecular sciences 20140516 5
A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-in ...[more]