Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells.
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ABSTRACT:
SUBMITTER: Forero A
PROVIDER: S-EPMC4058074 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells.
Forero Adriana A McCormick Kevin D KD Jenkins Frank J FJ Sarkar Saumendra N SN
Virology 20140505
Primary effusion lymphoma (PEL), associated with the latent infection by KSHV, constitutively expresses interferon-regulatory factor 4 (IRF4). We recently showed that IRF4 differentially regulates expression of cellular interferon-stimulated genes (ISGs) and viral genes (Forero et al., 2013). Here, using inducible IRF4 knockdown, we demonstrate that IRF4 silencing results in enhanced transcription of KSHV replication transactivator RTA. As a result viral transcription is increased leading to vir ...[more]
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