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An association study between genetic polymorphism in the interleukin-6 receptor gene and coronary heart disease.

ABSTRACT: The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese (P > 0.05). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans (P < 0.0001, odds ratio = 0.93, 95% confidential interval = 0.89-0.96). Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.

SUBMITTER: Zhou J

PROVIDER: S-EPMC4058185 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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An association study between genetic polymorphism in the interleukin-6 receptor gene and coronary heart disease.

Zhou Jiangqing J Chen Xiaoliang X Ye Huadan H Peng Ping P Ba Yanna Y Yang Xi X Huang Xiaoyan X Lu Yae Y Jiang Xin X Lian Jiangfang J Duan Shiwei S

BioMed research international 20140526

The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese (P > 0.05). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans (P < ...[more]

PMID: 24971337

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