Identification of microRNAs as potential biomarker for gastric cancer by system biological analysis.
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ABSTRACT:
SUBMITTER: Yan W
PROVIDER: S-EPMC4058523 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Identification of microRNAs as potential biomarker for gastric cancer by system biological analysis.
Yan Wenying W Wang Shouli S Sun Zhandong Z Lin Yuxin Y Sun Shengwei S Chen Jiajia J Chen Weichang W
BioMed research international 20140528
Gastric cancers (GC) have the high morbidity and mortality rates worldwide and there is a need to identify sufficiently sensitive biomarkers for GC. MicroRNAs (miRNAs) could be promising potential biomarkers for GC diagnosis. We employed a systematic and integrative bioinformatics framework to identify GC-related microRNAs from the public microRNA and mRNA expression dataset generated by RNA-seq technology. The performance of the 17 candidate miRNAs was evaluated by hierarchal clustering, ROC an ...[more]
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