Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC4059033 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Song He H Weitz Andrew C AC Hendrich Michael P MP Lewis Edwin A EA Emerson Joseph P JP
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20130607 6
Reengineering metalloproteins to generate new biologically relevant metal centers is an effective a way to test our understanding of the structural and mechanistic features that steer chemical transformations in biological systems. Here, we report thermodynamic data characterizing the formation of two type-2 copper sites in carbonic anhydrase and experimental evidence showing one of these new, copper centers has characteristics similar to a variety of well-characterized copper centers in synthet ...[more]