Ontology highlight
ABSTRACT:
SUBMITTER: Poplawski SE
PROVIDER: S-EPMC4059180 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Poplawski Sarah E SE Lai Jack H JH Li Youhua Y Jin Zhiping Z Liu Yuxin Y Wu Wengen W Wu Yong Y Zhou Yuhong Y Sudmeier James L JL Sanford David G DG Bachovchin William W WW
Journal of medicinal chemistry 20130429 9
Fibroblast activation protein (FAP) is a serine protease selectively expressed on reactive stromal fibroblasts of epithelial carcinomas. It is widely believed to play a role in tumor invasion and metastasis and therefore to represent a potential new drug target for cancer. Investigation into its biological function, however, has been hampered by the current unavailability of selective inhibitors. The challenge has been in identifying inhibitors that are selective for FAP over both the dipeptidyl ...[more]