Ontology highlight
ABSTRACT:
SUBMITTER: Livezey MR
PROVIDER: S-EPMC4059401 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Livezey Mara R MR Briggs Erran D ED Bolles Amanda K AK Nagy Leslie D LD Fujiwara Rina R Furge Laura Lowe LL
Xenobiotica; the fate of foreign compounds in biological systems 20130906 4
1. Metoclopramide is a widely used clinical drug in a variety of medical settings with rare acute dystonic events reported. The aim of this study was to assess a previous report of inactivation of CYP2D6 by metoclopramide, to determine the contribution of various CYPs to metoclopramide metabolism, and to identify the mono-oxygenated products of metoclopramide metabolism. 2. Metoclopramide interacted with CYP2D6 with Type I binding and a Ks value of 9.56 ± 1.09 µM. CYP2D6 was the major metabolize ...[more]