Ontology highlight
ABSTRACT:
SUBMITTER: Mederacke I
PROVIDER: S-EPMC4059406 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mederacke Ingmar I Hsu Christine C CC Troeger Juliane S JS Huebener Peter P Mu Xueru X Dapito Dianne H DH Pradere Jean-Philippe JP Schwabe Robert F RF
Nature communications 20130101
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the design of effective antifibrotic therapies. Different cellular sources, including tissue-resident and bone marrow-derived fibroblasts, pericytes and epithelial cells, have been suggested to give rise to myofibroblasts, but their relative contributions remain controversial, with profound differences between o ...[more]