Ontology highlight
ABSTRACT:
SUBMITTER: Goudriaan A
PROVIDER: S-EPMC4059439 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Goudriaan Andrea A de Leeuw Christiaan C Ripke Stephan S Hultman Christina M CM Sklar Pamela P Sullivan Patrick F PF Smit August B AB Posthuma Danielle D Verheijen Mark H G MH
Schizophrenia bulletin 20130816 4
Schizophrenia is a highly polygenic brain disorder. The main hypothesis for disease etiology in schizophrenia primarily focuses on the role of dysfunctional synaptic transmission. Previous studies have therefore directed their investigations toward the role of neuronal dysfunction. However, recent studies have shown that apart from neurons, glial cells also play a major role in synaptic transmission. Therefore, we investigated the potential causal involvement of the 3 principle glial cell lineag ...[more]