Ontology highlight
ABSTRACT:
SUBMITTER: Cerchia L
PROVIDER: S-EPMC4060133 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Cerchia Laura L Esposito Carla Lucia CL Camorani Simona S Catuogno Silvia S Franciscis Vittorio de V
Pharmaceuticals (Basel, Switzerland) 20111027 11
RNA-based approaches are among the most promising strategies aimed at developing safer and more effective therapeutics. RNA therapeutics include small non-coding miRNAs, small interfering RNA, RNA aptamers and more recently, small activating RNAs. However, major barriers exist to the use of RNAs as therapeutics such as resistance to nucleases present in biological fluids, poor chemical stability, need of specific cell targeted delivery and easy entry into the cell. Such issues have been addresse ...[more]