Ontology highlight
ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC4060247 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Xie Ling L Liu Cui C Wang Li L Gunawardena Harsha P HP Yu Yanbao Y Du Ruyun R Taxman Debra J DJ Dai Penggao P Yan Zhen Z Yu Jing J Holly Stephen P SP Parise Leslie V LV Wan Yisong Y YY Ting Jenny P JP Chen Xian X
Cell reports 20130221 3
MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases. Although gene-specific chromatin modifications regulate inflammation, the role of MyD88 signaling in establishing such epigenetic landscapes under different inflammatory states remains elusive. Using quantitative proteomics to enumerate the inflammation-phenotypic constituents of the MyD88 interactome, we found that in endotox ...[more]