Ontology highlight
ABSTRACT:
SUBMITTER: Schulz O
PROVIDER: S-EPMC4060605 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Schulz O O Ugur M M Friedrichsen M M Radulovic K K Niess J-H JH Jalkanen S S Krueger A A Pabst O O
Mucosal immunology 20131218 4
Lymphoid organ hypertrophy is a hallmark of localized infection. During the inflammatory response, massive changes in lymphocyte recirculation and turnover boost lymphoid organ cellularity. Intriguingly, the exact nature of these changes remains undefined to date. Here, we report that hypertrophy of Salmonella-infected Peyer's patches (PPs) ensues from a global "shutdown" of lymphocyte egress, which traps recirculating lymphocytes in PPs. Surprisingly, infection-induced lymphocyte sequestration ...[more]