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Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin.

ABSTRACT: Synchronization of the mammalian master circadian pacemaker to the daily light/dark cycle is mediated exclusively through retinal photoreceptors. The mammalian retina itself is also a self-sustained circadian oscillator. Here we report that the retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment. In vivo, retinas of Opn4(-/-);rd1/rd1 mice synchronize to light/dark cycles regardless of the phase of the master circadian pacemakers of the suprachiasmatic nuclei or the behavior of the animal. These data demonstrate that the retina uses a separate mechanism for local entrainment of its circadian clock than for entrainment of organism-level rhythmicity.

SUBMITTER: Buhr ED

PROVIDER: S-EPMC4060676 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin.

Buhr Ethan D ED Van Gelder Russell N RN

Proceedings of the National Academy of Sciences of the United States of America 20140519 23

Synchronization of the mammalian master circadian pacemaker to the daily light/dark cycle is mediated exclusively through retinal photoreceptors. The mammalian retina itself is also a self-sustained circadian oscillator. Here we report that the retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment. In vivo, retinas of Opn4(-/-);rd1/rd1 mice synchronize to light/dark cycles regardless of th ...[more]

PMID: 24843129

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