Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Rohrer BB
PROVIDER: S-EPMC4060687 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Diaz-Rohrer Blanca B BB Levental Kandice R KR Simons Kai K Levental Ilya I
Proceedings of the National Academy of Sciences of the United States of America 20140527 23
The lipid raft hypothesis proposes lateral domains driven by preferential interactions between sterols, sphingolipids, and specific proteins as a central mechanism for the regulation of membrane structure and function; however, experimental limitations in defining raft composition and properties have prevented unequivocal demonstration of their functional relevance. Here, we establish a quantitative, functional relationship between raft association and subcellular protein sorting. By systematic ...[more]