Ontology highlight
ABSTRACT:
SUBMITTER: VanderMolen KM
PROVIDER: S-EPMC4061710 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
VanderMolen Karen M KM Darveaux Blaise A BA Chen Wei-Lun WL Swanson Steven M SM Pearce Cedric J CJ Oberlies Nicholas H NH
RSC advances 20140101 35
The use of epigenetic modifiers, such as histone deacetylase inhibitors and DNA methyltransferase inhibitors, has been explored increasingly as a technique to induce the production of additional microbial secondary metabolites. The application of such molecules to microbial cultures has been shown to upregulate otherwise suppressed genes, and in several cases has led to the production of new molecular structures. In this study, the proteasome inhibitor bortezomib was used to induce the productio ...[more]