Unknown

Dataset Information

0

Treating human autoimmunity: current practice and future prospects.


ABSTRACT: Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be overcome to target these therapies to patients suffering from autoimmune disease while avoiding the pitfalls of general immunosuppression.

SUBMITTER: Rosenblum MD 

PROVIDER: S-EPMC4061980 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Treating human autoimmunity: current practice and future prospects.

Rosenblum Michael D MD   Gratz Iris K IK   Paw Jonathan S JS   Abbas Abul K AK  

Science translational medicine 20120301 125


Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be ov  ...[more]

Similar Datasets

| S-EPMC7209938 | biostudies-literature
| S-EPMC8078400 | biostudies-literature
| S-EPMC7468195 | biostudies-literature
| S-EPMC5868572 | biostudies-literature
| S-EPMC6165730 | biostudies-literature
| S-EPMC8903790 | biostudies-literature
| S-EPMC5628252 | biostudies-literature
| S-EPMC6029608 | biostudies-literature
| S-EPMC5784843 | biostudies-other
| S-EPMC3206119 | biostudies-other