Treating human autoimmunity: current practice and future prospects.
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ABSTRACT:
SUBMITTER: Rosenblum MD
PROVIDER: S-EPMC4061980 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Treating human autoimmunity: current practice and future prospects.
Rosenblum Michael D MD Gratz Iris K IK Paw Jonathan S JS Abbas Abul K AK
Science translational medicine 20120301 125
Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be ov ...[more]
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