Ontology highlight
ABSTRACT:
SUBMITTER: Cai H
PROVIDER: S-EPMC4061987 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Cai Huaqing H Katoh-Kurasawa Mariko M Muramoto Tetsuya T Santhanam Balaji B Long Yu Y Li Lei L Ueda Masahiro M Iglesias Pablo A PA Shaulsky Gad G Devreotes Peter N PN
Science (New York, N.Y.) 20140301 6177
Biological oscillations are observed at many levels of cellular organization. In the social amoeba Dictyostelium discoideum, starvation-triggered multicellular development is organized by periodic cyclic adenosine 3',5'-monophosphate (cAMP) waves, which provide both chemoattractant gradients and developmental signals. We report that GtaC, a GATA transcription factor, exhibits rapid nucleocytoplasmic shuttling in response to cAMP waves. This behavior requires coordinated action of a nuclear local ...[more]