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Touch spray mass spectrometry for in situ analysis of complex samples.


ABSTRACT: Touch spray, a spray-based ambient in situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization.

SUBMITTER: Kerian KS 

PROVIDER: S-EPMC4063212 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Touch spray mass spectrometry for in situ analysis of complex samples.

Kerian Kevin S KS   Jarmusch Alan K AK   Cooks R Graham RG  

The Analyst 20140601 11


Touch spray, a spray-based ambient in situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization. ...[more]

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