Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC4063271 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Zhou Xinzhi X Smith Andrew J H AJ Waterhouse Anna A Blin Guillaume G Malaguti Mattias M Lin Chia-Yi CY Osorno Rodrigo R Chambers Ian I Lowell Sally S
Stem cells (Dayton, Ohio) 20130801 8
Robust development of the early embryo may benefit from mechanisms that ensure that not all pluripotent cells differentiate at exactly the same time: such mechanisms would build flexibility into the process of lineage allocation. This idea is supported by the observation that pluripotent stem cells differentiate at different rates in vitro. We use a clonal commitment assay to confirm that pluripotent cells commit to differentiate asynchronously even under uniform differentiation conditions. Stoc ...[more]