Ontology highlight
ABSTRACT:
SUBMITTER: Faust JE
PROVIDER: S-EPMC4063865 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Faust Joseph E JE Manisundaram Arvind A Ivanova Pavlina T PT Milne Stephen B SB Summerville James B JB Brown H Alex HA Wangler Michael M Stern Michael M McNew James A JA
PloS one 20140619 6
Peroxisomes are ubiquitous organelles that perform lipid and reactive oxygen species metabolism. Defects in peroxisome biogenesis cause peroxisome biogenesis disorders (PBDs). The most severe PBD, Zellweger syndrome, is characterized in part by neuronal dysfunction, craniofacial malformations, and low muscle tone (hypotonia). These devastating diseases lack effective therapies and the development of animal models may reveal new drug targets. We have generated Drosophila mutants with impaired per ...[more]