Diagnosis of covert hepatic encephalopathy without specialized tests.

ABSTRACT:

Background & aims

Covert hepatic encephalopathy (CHE) impairs quality of life (QOL) and can be difficult to diagnose. Patient-administered methods that do not require specialized tests or equipment might increase rates of detection. We performed a longitudinal study to determine whether demographic data and responses to a validated QOL questionnaire, the Sickness Impact Profile (SIP), can identify patients with CHE.

Methods

Patients with cirrhosis without prior overt HE were recruited from outpatient liver clinics at the Virginia Commonwealth University Medical Center, from August 2008 through February 2012. We performed cognitive tests on 170 patients (mean age, 55 y; mean model for end-stage liver disease score, 9; 50% with hepatitis C-associated and 11% with alcohol-assoc

SUBMITTER: Nabi E 

PROVIDER: S-EPMC4063880 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature