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A novel cell death gene acts to repair patterning defects in Drosophila melanogaster.


ABSTRACT: Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development.

SUBMITTER: Tanaka KM 

PROVIDER: S-EPMC4063928 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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A novel cell death gene acts to repair patterning defects in Drosophila melanogaster.

Tanaka Kentaro M KM   Takahashi Aya A   Fuse Naoyuki N   Takano-Shimizu-Kouno Toshiyuki T  

Genetics 20140325 2


Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development. ...[more]

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