Dataset Information

Acute hepatitis C in HIV-1 infected Japanese Cohort: single center retrospective cohort study.

ABSTRACT:

Objectives

HCV co-infection is a poor prognostic factor in HIV-1-infected patients. Although the number of newly reported patients who show seroconversion is increasing, the clinical features are still unclear, especially in Asian countries.

Design

A single-center retrospective cohort study of patients diagnosed between 2001-2012.

Methods

Acute hepatitis C (AHC) was diagnosed upon detection of high serum ALT (>100 IU) followed by anti-HCV seroconversion. Clinical characteristics, HIV-1-related immunological status and IL-28B genotypes (rs12979860, rs8099917) were collected. We compared these variables between patients with and without spontaneous clearance of HCV and between responders and non-responders to treatment with pegylated interferon (PEG-IFN) plus ribavirin.

Results

Thirty-five patients were diagnosed with AHC during the study period. The majority (96.9%) were MSM. Three were lost to follow-up. Seventy-five percent of patients with AHC (24/32) were asymptomatic and found incidentally to have high serum ALT. Compared to those who did not show spontaneous clearance, patients with spontaneous HCV viral clearance showed more symptoms and more severe abnormalities related to acute hepatitis. Spontaneous clearance was seen in 4 out of 28 patients with CC+TT genotype, but not in 6 patients with IL-28B CT+TG genotype. PEG-IFN plus ribavirin treatment was initiated in 12 out of 28 cases without spontaneous clearance. The sustained virological response rate was high (81.8%, 9/11), even in cases with CT+TG genotype infected with HCV genotype 1b (SVR 2/2).

Conclusions

Careful attention to AHC is needed in HIV-1-infected MSM. Early diagnosis and PEG-IFN plus ribavirin treatment should be considered for AHC cases.

SUBMITTER: Ishikane M

PROVIDER: S-EPMC4063971 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Acute hepatitis C in HIV-1 infected Japanese Cohort: single center retrospective cohort study.

Ishikane Masahiro M Watanabe Koji K Tsukada Kunihisa K Nozaki Yuichi Y Yanase Mikio M Igari Toru T Masaki Naohiko N Kikuchi Yoshimi Y Oka Shinichi S Gatanaga Hiroyuki H

PloS one 20140619 6

<h4>Objectives</h4>HCV co-infection is a poor prognostic factor in HIV-1-infected patients. Although the number of newly reported patients who show seroconversion is increasing, the clinical features are still unclear, especially in Asian countries.<h4>Design</h4>A single-center retrospective cohort study of patients diagnosed between 2001-2012.<h4>Methods</h4>Acute hepatitis C (AHC) was diagnosed upon detection of high serum ALT (>100 IU) followed by anti-HCV seroconversion. Clinical characteri ...[more]

PMID: 24945812

Similar Datasets

Project description:BackgroundTreatment with tenofovir is sometimes associated with renal dysfunction. Limited information is available on this side effect in patients with small body weight, although the use of tenofovir will spread rapidly in Asia and Africa, where patients are likely to be of smaller body weight.MethodsIn a single-center cohort, Japanese patients with HIV infection who started tenofovir-containing antiretroviral therapy were retrospectively analyzed. The incidence of tenofovir-associated renal dysfunction, defined as more than 25% decrement of estimated glomerular filtration rate (eGFR) from the baseline, was determined. The effects of small body weight and body mass index (BMI) on tenofovir-associated renal dysfunction, respectively, were estimated in univariate and multivariate Cox hazards models as the primary exposure. Other possible risk factors were evaluated by univariate analysis and those found significant were entered into the multivariate analysis.ResultsThe median weight of 495 patients was 63 kg. Tenofovir-related renal dysfunction occurred in 97 (19.6%) patients (incidence: 10.5 per 100 person-years). Univariate analysis showed that the incidence of tenofovir-related renal dysfunction was significantly associated with smaller body weight and BMI, respectively (per 5 kg decrement, HR?=?1.23; 95% CI, 1.10-1.37; p<0.001)(per 1 kg/m(2) decrement, HR?=?1.14; 95% CI, 1.05-1.23; p?=?0.001). Old age, high baseline eGFR, low serum creatinine, low CD4 count, high HIV viral load, concurrent nephrotoxic drugs, hepatitis C infection, and current smoking were also associated with tenofovir-related renal dysfunction. Multivariate analysis identified small body weight as a significant risk (adjusted HR?=?1.13; 95% CI, 1.01-1.27; p?=?0.039), while small BMI had marginal significance (adjusted HR?=?1.07; 95% CI 1.00-1.16; p?=?0.058).ConclusionThe incidence of tenofovir-associated renal dysfunction in Japanese patients was high. Small body weight was identified as an independent risk factor for tenofovir-associated renal dysfunction. Close monitoring of renal function is advocated for patients with small body weight treated with tenofovir.

Dataset Information

Acute hepatitis C in HIV-1 infected Japanese Cohort: single center retrospective cohort study.

Objectives

Design

Methods

Results

Conclusions

Publications

Acute hepatitis C in HIV-1 infected Japanese Cohort: single center retrospective cohort study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets