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Beam path toxicity in candidate organs-at-risk: assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy.


ABSTRACT: BACKGROUND:To investigate potential dose-response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of interest (CNV-ROIs) in head and neck (HNC) squamous cell carcinomas. METHODS AND MATERIAL:A total of 130 patients treated with IMRT with squamous cell carcinomas of head and neck were evaluated. For each patient, CNV-ROIs were segmented manually on planning CT images. Clinical on-treatment RANV data were reconstructed by a review of the records for all patients. Dosimetric data parameters were recorded from dose-volume histograms. Nausea and vomiting reports were concatenated as a single binary "Any N/V" variable, and as a "CTC-V2+" variable. RESULTS:The mean dose to CNV-ROIs was higher for patients experiencing RANV events. For patients receiving IMRT alone, a dose-response effect was observed with varying degrees of magnitude, at a statistically significant level for the area postrema, brainstem, dorsal vagal complex, medulla oblongata, solitary nucleus, oropharyngeal mucosa and whole brain CNV-ROIs. CONCLUSION:RANV is a common therapy-related morbidity facing patients receiving HNC radiotherapy, and, for those receiving radiotherapy-alone, is associated with modifiable dose to specific CNS structures.

SUBMITTER: Kocak-Uzel E 

PROVIDER: S-EPMC4063998 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Beam path toxicity in candidate organs-at-risk: assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy.

Kocak-Uzel Esengul E   Gunn G Brandon GB   Colen Rivka R RR   Kantor Micheal E ME   Mohamed Abdallah S R AS   Schoultz-Henley Sara S   Mavroidis Paniyotis P   Frank Steven J SJ   Garden Adam S AS   Beadle Beth M BM   Morrison William H WH   Phan Jack J   Rosenthal David I DI   Fuller Clifton D CD  

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20140417 2


<h4>Background</h4>To investigate potential dose-response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of interest (CNV-ROIs) in head and neck (HNC) squamous cell carcinomas.<h4>Methods and material</h4>A total of 130 patients treated with IMRT with squamous cell carcinomas of head and neck were evaluated. For each patient, CNV-ROIs were segmented manually on planning CT images. Clinical on-trea  ...[more]

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