Ontology highlight
ABSTRACT:
SUBMITTER: Bachanova V
PROVIDER: S-EPMC4064329 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Bachanova Veronika V Cooley Sarah S Defor Todd E TE Verneris Michael R MR Zhang Bin B McKenna David H DH Curtsinger Julie J Panoskaltsis-Mortari Angela A Lewis Dixie D Hippen Keli K McGlave Philip P Weisdorf Daniel J DJ Blazar Bruce R BR Miller Jeffrey S JS
Blood 20140409 25
Haploidentical natural killer (NK) cell infusions can induce remissions in some patients with acute myeloid leukemia (AML) but regulatory T-cell (Treg) suppression may reduce efficacy. We treated 57 refractory AML patients with lymphodepleting cyclophosphamide and fludarabine followed by NK cell infusion and interleukin (IL)-2 administration. In 42 patients, donor NK cell expansion was detected in 10%, whereas in 15 patients receiving host Treg depletion with the IL-2-diphtheria fusion protein ( ...[more]